Composition: Shynem | Brand: Shynem


TYPE: Tablet


Ibuprofen BP 400 mg

Ibuprofen is a propionic acid derivative with analgesic, anti-inflammatory and anti-pyretic activity. The non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, mild aches. It works by reducing body's production of prostaglandin synthesis that causes inflammation. This effect helps to decrease swelling, pain, or fever.


  • Ibuprofen is indicated for its analgesic and anti-inflammatory effects in the treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and other non-rheumatoid arthropathies.
  • In the treatment of non-articular rheumatic conditions. Ibuprofen is indicated in periarticular conditions such as frozen shoulder (capsulitis), bursitis, tendonitis, tenosynovitis and low back pain and can also be used in soft tissue injuries such as sprains and strains.
  • Ibuprofen is also indicated for its analgesic effect in the relief of mild to moderate pain such as dysmenorrhoea, dental and post-operative pain and for symptomatic relief of headache, including migraine headache.

Dosage and Directions for use:

The recommended dosage of Ibuprofen is 1200-1800 mg daily in divided doses. Some patients require 600-1200 mg daily. In severe or acute conditions, increase the dosage but the total daily dose does not exceed 2400 mg in divided doses.

Children: The daily dosage is 20 mg/kg of body weight in divided doses.

In Juvenile Rheumatoid Arthritis, up to 40mg/kg of body weight daily in divided doses.

Not recommended for children weighing less than 7 kg.


 The dosage should be used for the shortest possible duration. If an NSAID is considered necessary, the lowest effective dose should be used. Increase the dose at a risk of serious consequences of adverse reactions.

To be taken preferably with or after food.


  • Hypersensitivity to Ibuprofen
  • Hypersensitivity to Aspirin or other non-steroidal anti-inflammatory drugs.
  • History of gastrointestinal disease like GI bleeding, ulceration or perforation which can be fatal and related to previous NSAIDs therapy.
  • Active or history of recurrent peptic ulcer/haemorrhage
  • Severe heart failure, renal failure or hepatic failure
  • Last trimester of pregnancy.

Special Warnings and Precautions:

  • The elderly have an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation.
  • The use of Ibuprofen with concomitant NSAIDs including cyclooxygenase-2 selective inhibitors should be avoided.
  • Patients with rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose-galactose malabsorption should not take this medication.
  • Bronchospasm may be precipitated in patients suffering from the previous history of bronchial asthma.
  • Renal impairment and Hepatic dysfunction
  • Systemic lupus erythematosus and mixed connective tissue disease- increased risk of aseptic meningitis.
  • History of hypertension or heart failure as fluid retention, hypertension and oedema.
  • Serious skin reactions like exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis.
  •  There is a risk of renal impairment in dehydrated children and adolescents.



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